Trophoblastic tissue

Gestational Trophoblastic Disease Treatment (PDQ®)-Patient

Gestational trophoblastic neoplasia (GTN) - Gestational neoplasms include: choriocarcinoma, placental site trophoblastic tumor, epithelioid trophoblastic tumor, and invasive mole. In the absence of tissue for a definitive histopathologic diagnosis, disease diagnosed as a result of persistent elevation of human chorionic gonadotropin (hCG. trophoblast the outermost layer of cells surrounding the BLASTOCYST, consisting of embryonic epithelium, which subsequently encloses all the embryonic structures of the developing mammal and forms the outer layer of the CHORION and the embryonic side of the placenta Beard found other trophoblastic cells lying dormant throughout the body, and he called them germ cells. As we age, or in a combination of other factors, the cells receive a signal that causes them to begin growing in an attempt to become trophoblast tissue The presence of an implantation site, chorionic villi, or trophoblastic tissue in uterine curettage samples is conventionally held as definitive evidence of an intrauterine pregnancy. We present a series of four cases that challenge this convention

There are several forms of hydatidiform mole: partial mole, complete mole and persistent gestational trophoblastic tumor. Many of these tumours arise from a haploid sperm fertilizing an egg without a female pronucleus (the alternative form, an embryo without sperm contribution, is called parthenogenesis) About persistent trophoblastic disease and choriocarcinoma Persistent trophoblastic disease is when women who have had treatment to remove a molar pregnancy from the womb still have some molar tissue left behind. This occurs in about 1 in 12 women (8%) after a molar pregnancy

Those parts that remain in the uterus after delivery are called the placental bed and consist mainly of intact and necrotic endometrial tissue, with intermingled trophoblastic cells. With expansion of the placenta, within in few days the trophoblastic shell is disrupted into multiple clusters of proliferating extravillous trophoblast The gestational trophoblastic diseases (GTDs) are a complex family of disorders. The term GTD is a general one, used to describe any of the group of diagnoses that behave out of character from what is expected of gestational trophoblastic tissue. The term GTD refers to both benign and malignant conditions submit tissue for histopathology to appropriately manage the patient, particularly with post-molar GTD (Table 1). Persistent trophoblastic disease after Florid trophoblastic proliferation in early pregnancy and tubal ectopic pregnancy An area of challenge is the exuberant trophoblas Gestational trophoblastic disease (GTD) forms a group of disorders spanning the conditions of complete andpartial molar pregnancies through to the malignant conditions of invasive mole, choriocarcinoma and the veryrare placental site trophoblastic tumour (PSTT). There are reports of neoplastic transformation of atypicalplacental site nodules to placental site trophoblastic tumour Gestational trophoblastic disease (GTD) is a term used to describe a group of pregnancy-related tumours. They can be divided into two main groups: Pre-malignant conditions (more common) - such as partial molar pregnancy and complete molar pregnancy

Trophoblast - Libre Patholog

  1. trophoblast [ trō ′fə-blăst′ ] The outermost layer of cells of the blastocyst, which attaches the fertilized ovum to the uterine wall and serves as a nutritive pathway for the embryo. The trophoblast eventually differentiates into such tissues as the amnion, the placenta, and the umbilical cord
  2. The results of this study indicate that selective HR of residual trophoblastic tissue significantly reduces the incidence of intrauterine adhesions and increases pregnancy rates
  3. Healthy trophoblastic tissue penetrates the endometrium, which creates a rich uterine vasculature, leading to a close connection between the fetus and the mother, which is called the placenta. Invasion is characteristic of malignant tissue, and fortunately, the malignant behavior of the healthy trophoblast is well controlled
  4. Gestational Trophoblastic Disease. Gestational trophoblastic disease is proliferation of trophoblastic tissue in pregnant or recently pregnant women. Manifestations may include excessive uterine enlargement, vomiting, vaginal bleeding, and preeclampsia, particularly during early pregnancy. Diagnosis includes measurement of the beta subunit of.
  5. In trophoblastic tissues a high velocity, low resistance flow is consistent with increased vascularity. Thus, use of color Doppler imaging may help differentiate molar pregnancy from mimics such as missed abortion [ 10, 27 ]. Uterine Artery Doppler Measurement in Molar Pregnancy and Development of GT

Trophoblast - Wikipedi

  1. trophoblastic tissue and to evaluate local spread. Chest imaging is also required as the lungs are the most common site of metastases. In the absence of pulmonary and vaginal involvement, brain and liver metastases are rare and further radiologic testing may not be needed. However
  2. Columns and sheets of trophoblastic tissue invade normal tissues and spread to distant sites, the most common of which are lungs, brain, liver, pelvis, vagina, spleen, intestines, and kidney. Most choriocarcinomas have an aneuploid karyotype, and about three-quarters of them contain a Y chromosome
  3. In most molar pregnancies, any remaining abnormal tissue in the womb usually dies off. But in a small proportion of women, the tissue can remain and grow further into the lining of the womb and, like a cancer, spread to other areas of the body. This is known as persistent trophoblastic disease. Vaginal bleeding is the most common symptom
  4. es the subtypes of GTD, and their treatment
  5. ate trophoblastic tissue through the venous system. 26 This is known to occur in normal pregnancy, especially when uterine activity is increased, such as with placental abruption. The.
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n. In this group of patients, the clinician must rely on microscopic examination of products of conception in a uterine curettage specimen to rule out the presence of an extrauterine pregnancy. The presence of an implantation site, chorionic villi, or trophoblastic tissue in uterine curettage samples is conventionally held as definitive evidence of an intrauterine pregnancy. We present a. Medical evacuation of complete molar pregnancies should be avoided if possible.Oxytocic agents are not routinely used because of the potential to embolise and disseminate trophoblastic tissue. After a molar pregnancy has been removed, molar tissue may remain and continue to grow. This is called persistent gestational trophoblastic neoplasia (GTN). This occurs in about 15% to 20% of complete molar pregnancies, and up to 5% of partial molar pregnancies

Gestational trophoblastic disease Radiology Reference

Gestational choriocarcinoma. Gestational choriocarcinoma (GTD) is a malignancy that arises from trophoblastic tissue of term pregnancies, ectopic pregnancies, spontaneous/induced abortions or molar pregnancies (Berkowitz et al, 1984). It occurs in approximately 1 in 50,000 pregnancies. The primary symptoms are irregular vaginal bleeding. Placental site trophoblastic tumor may present as a heterogenous endometrial + myometrial mass although appearances on MRI can be non-specific. The junctional zone is disrupted. In the majority of the cases, there are cystic spaces and vascular structures. Reported signal characteristics include 1,3 In addition, removal of the hydatidiform mole or trophoblastic tumour results in the rapid resolution of hyperthyroidism. These findings point to the trophoblastic tissue as the main source of the thyroid stimulating agent . hCG has thyrotropic activities and plays a central role in mediating hyperthyroidism in GTD [20,21,22] Plausibility of trophoblastic-like regulation of cancer tissue. Background: Thus far, a well-established logical pattern of malignancy does not exist. The current approach to cancer properties is primarily descriptive with usually, for each of them, extensive analyses of the underlying associated biomolecular mechanisms

Trophoblastic tumours Cytotrophoblast is the proliferative component, while syncytiotrophoblast is terminally differentiated. Intermediate trophoblast differentiates from the trophoblastic columns that anchor the chorionic villi to the endometrium and are of an intermediate degree of differentiation @article{osti_5880649, title = {Persistent trophoblastic tissue following salpingostomy for unruptured ectopic pregnancy}, author = {Rivlin, M E and Meeks, G R and Cowan, B D and Bates, G W}, abstractNote = {Radioimmunoassay of beta-hCG was used to diagnose an ectopic pregnancy in a 30 year old patient and the site of pregnancy was determined by ultrasonography

Hence, acquisition of the trophoblastic logistic properties, normally dormant, would explain the invasive behavior of cancer cells and the distinctive hijacking, to their advantage, of the host tissue functions. Both trophoblastic and cancer cells have a comprehensive set of pro-survival functions devoted to fast growth of semi-foreign. trophoblast. ( ˈtrɒfəˌblæst) n. (Biology) the outer layer of cells of the embryo of placental mammals, which is attached to the uterus wall and absorbs nourishment from the uterine fluids. [C19: from tropho- + -blast shTi si a rocccaomhriiaon, ro a aerr lngnmatia tiraotbpclhso turmo pdlodveee e/fatrdinugr yrcangepn 2F[2A00 62]4p.It si iaareehdcztcr by eadirnces msreu baet GhC dan lalbnoannc ematsasste ot het gunl. Bisypo ludwo wsho tohtposbrlcai sitsue whit no oonhcicir lilvi t.prnes hydatidiform mole: Definition A hydatidiform mole is a relatively rare condition in which tissue around a fertilized egg that normally would have developed into the placenta instead develops as an abnormal cluster of cells. (This is also called a molar pregnancy.) This grapelike mass forms inside of the uterus after fertilization instead of a. tissue, it is classified as a hydatidiform mole with malig- nant-appearing trophoblastic tissue. Choriocarcinoma is associated with hemorrhage, necrosis, and vascular invasion. It always produces hCG, metastasizes early and widely, and was considered one of the most fatal human malignancies before the development of eff ec- tive chemotherapy

Investigations in recent decades have exploited tissue DNA genotyping as a powerful ancillary tool for the precision diagnosis and subclassification of gestational trophoblastic disease. As. Radiology 1986; no residual trophoblastic tissue could curettage have 158:393. been avoided. A similar rate of cases (59.2%) with no 3. Ellish NJ, Chen HC, Jason C, Janerich DT. Pilot study to residual trophoblastic tissue could be predicted by the detect early pregnancy and early fetal loss A well recognized complication of conservative surgical treatment for tubal ectopic pregnancy, salpingotomy, is incomplete removal of trophoblastic tissue. Secondary trophoblastic implantation needs to be considered especially in cases of persistent disease following salpingectomy. We report an unusual and rare case of persistent peritoneal trophoblastic implantation following salpingotomy.

Gestational trophoblastic disease - Wikipedi

Residual trophoblastic tissue was confirmed by histologic examination in all 12 patients (100%). In 4 patients from group 2 who underwent sur- gical hysteroscopy because of bleeding or phy- sician uncertainty, histologic examination revealed either blood clots or a decidual reac- tion. Ultrasonography, done after menstruation in the other 7. van den Bosch T, Daemen A, Van Schoubroeck D, et al. Occurrence and outcome of residual trophoblastic tissue: a prospective study. J Ultrasound Med 2008; 27:357. Akiba N, Iriyama T, Nakayama T, et al. Ultrasonographic vascularity assessment for predicting future severe hemorrhage in retained products of conception after second-trimester abortion Gestational trophoblastic disease is a group of diseases originating from fetal khorion characterized by abnormal trophoblastic tissue proliferation. 20 Martaadisoebrata found that 36.6% of mola patients who had become choriocarcinomas had an excessive proliferation of trophoblastic cells compared to 10% of those without malignancy. 7 While. Abstract. The use of human chorionic gonadotropin (hCG), human placental lactogen (hPL), and pregnancy-specific beta-l-glycoprotein (SP 1) as markers for trophoblastic tissue is well documented in the literature.However, it is not widely recognized that cytokeratin is a very sensitive and reliable marker for all types of trophoblastic tissues

The classic description of gestational trophoblastic tissue is a bunch of grapes. Microscopically, diffuse villous enlargement with hydropic changes can be observed. There is almost always some degree of cytologic atypia with many cells being mitotically active. Central cisterns, as well as trophoblastic hyperplasia, will also be present FIGURE 29-8 Doppler spectral analysis from trophoblastic tissue in a patient with an invasive mole demonstrating flow velocity waveforms with low resistance. FIGURE 29-9 A and B. Extension of an invasive mole (arrows) into the myometrium in two patients with markedly elevated hCG levels PARTIAL H. Mole• Characterized by:1. Chorionic villi of varying size with focal hydatidiform swelling, cavitation and trophoblastic hyperplasia.2. Marked villous scalloping3. Prominent stromal trophoblastic inclusions4. Identifiable fetal or embryonic tissues.• Karyotype: triploid, the extra haploid set is derived from father. Finding a tumor marker to predict the aggressive behavior of molar pregnancy in early stages has yet been a topic for studies.In this survey we planned to study patients with molar pregnancy to 1) assess the p53 and c-erbB-2 expression in trophoblastic tissue, 2) to study the relationship between their expression intensity and progression of a molar pregnancy to gestational trophoblastic.

What Is Gestational Trophoblastic Disease

Salpingostomy is, however, associated with a 5-8% risk of persistent trophoblastic tissue and is less cost effective as a result of the subsequent monitoring and treatment that this necessitates . Salpingectomy is considered preferable when there is significant haemorrhage and/or damage to the tube, when ectopic pregnancy has recurred in the. This hormone is produced by the trophoblastic tissue. It is the hormone that is detected in a standard pregnancy test. The high levels of hCG occur because there is an excessive amount of trophoblastic tissue with a hydatidiform mole. The high hCG levels are responsible for some of the symptoms. Pregnancy symptoms the proliferative potential of ectopic trophoblastic tissue and compare ectopic to intrauterine pregnancies, as well as evaluat-ing differences between individual tubal pregnancies. More-over, the immunohistochemical Ki-67 proliferation rate has been compared to the maternal serum p-HCG values, as the Introduction. Residual trophoblastic tissue complicates nearly 1% of all pregnancies. It occurs most commonly after termination of pregnancy, but may also occur following spontaneous vaginal delivery and Caesarean section (Achiron et al., 1993; Zalel et al., 2001).Common symptoms include fever, vaginal bleeding and abdominal or pelvic pain


The value of transvaginal B-mode ultrasonography combined with color velocity imaging and pulsed Doppler to detect retained trophoblastic tissue was evaluated prospectively in a series of 40 patients with postpartum (n = 15) or postabortion (n = 25) bleeding. Color velocity imaging was used to identify color-coded blood flow signals within. Trophoblastic changes in placenta tissue. S/S- bleeding, hyperemesis, drastically elevated hCG, large for dates, no FHR, low AFP, preeclampsia. Sono- small cystic structures in uterus, vascular, bilateral theca lutein cysts. May see fetus or not. Incomplete abortio BACKGROUND: Gestational trophoblastic disease (GTD) encompasses a group of disorders that arise from abnormal growth of trophoblastic tissue.The spectrum of GTD includes 2 major groups: benign and malignant. The benign form is a hydatidiform mole, either complete or partial; the malignant forms, referred to as gestational trophoblastic neoplasia (GTN), consist of invasive moles. In this study, patient-, disease-, and treatment-related characteristics of 83 patients diagnosed with GTN at the New England Trophoblastic Disease Center and treated with EMA (44 individuals) or.

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Secretion of interferon tau (IFNt) by trophoblastic tissue has been shown to be the first embryonic signal for pregnancy recognition. Therefore we tried to derive biologically active trophoblastic tissue by in vitro techniques. Since conventional in vitro conditions for bovine embryo development were not sufficient. gestational trophoblastic disease (GTD) abnormal proliferation of trophoblastic tissue. categories of GTD. molar pregnancies, persistent/invasive moles, choriocarcinoma, and rare placental site trophoblastic tumors. GTD tissue. fetal tissue, not maternal. produced by GTD. HCG. incidence of molar pregnancy Inhibin can also be demonstrated in choriocarcinoma and in nongestational trophoblastic tissue. Inhibin is a sensitive marker of syncytiotrophoblast and staining with this antibody may prove useful in the diagnosis of choriocarcinoma and in the demonstration of trophoblastic cells in germ cell tumours These pregnancies lack an embryo and have abnormal growth of trophoblastic tissue. The body can abort hydatidiform moles completely (spontaneous abortion or miscarriage). If they do not abort completely, the woman will need a procedure to completely remove the abnormal tissue from the uterus. GTD can occur: during a pregnanc

Gestational trophoblastic disease (GTD) is the name given to a group of rare tumors that develop during early pregnancy. After conception, tissue grows to form part of the placenta and surrounds the fertilized egg in the uterus, forming what's called a trophoblast Gestational trophoblastic disease (GTD) is a group of rare tumors that begin during a pregnancy. These tumors start in the cells that would normally develop into the placenta, which connects the fetus to the uterus. The tumors typically are diagnosed in women at the early or late stages of childbearing potential, usually in patients under age. The tumor always follows pregnancy, most often molar pregnancy (hydatidiform mole; see this term). Four histological subtypes have been described: invasive mole, gestational choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor (see these terms) Gestational trophoblastic disease (GTD) affects the uterus. The uterus is a part of the female reproductive system. It is pear-shaped, hollow, and located in the pelvis between the bladder and rectum. The uterus is also known as the womb, where a fetus or unborn baby, grows during pregnancy. The uterus has 2 sections: the cervix, which is the.

Trophoblast definition of trophoblast by Medical dictionar

Dr John Beard's Trophoblastic Theory of Cancer Causatio

trophoblastic tissue is found; less frequently, a polypoid or pedunculated mass of placental tissue (placental polyp) is found. In such cases, evacuation of the retained tissue is necessary to stop bleeding,resolvetheinfection,andpreventlong-termcomplication The presence of persistent trophoblastic tissue within the fallopian tube is commonly seen to occur after conservative surgery in the form of salpingotomy or fimbrial expression for ectopic pregnancy. However, the occurrence of primary persistent peritoneal trophoblastic implants is a rare phenomenonl . Very fe Contains fetal or embryonic parts in addition to trophoblastic tissue; Caused by fertilization of an egg containing a haploid set of chromosomes with two sperms (each of them containing a haploid set of chromosomes as well) Fetal karyotypes; : 69XXX, 69XXY, 69XYY; Complete mole is the result of paternal disomy. Partial mole is the result of. Gestational trophoblastic disease. Product of an abnormal conception lacking identifiable embryonic or fetal tissue. Chorionic villi with generalized hydropic swelling. Diffuse trophoblastic hyperplasia. Implantation-site trophoblast with diffuse and marked atypia. Presence of identifiable embryonic or fetal tissues

Seminar on gestational trophoblastic disease (gtd) (f inal)

Chorionic villi or trophoblastic tissue in uterine samples

- Culture failure rate for fresh tissue: ~14% - Only paraffin embedded tissue available • Uncharacterized structural abnormality - Marker chromosome trophoblastic hypoplasia may also be seen (e.g. trisomy 18) Villous edema / hydrops . Incidental Trisomy Detectio Gestational trophoblastic disease (GTD) is an umbrella term for a group of rare diseases in which abnormal trophoblast cells grow inside the uterus after conception. According to the National Cancer Institute, after conception, a tumor develops inside the uterus from tissue that is composed of trophoblast cells Gestational trophoblastic tissue forms from the peripheral cells of the blastocyst a few days after conception. The tissue is divided into two layers: the outer syncytiotrophoblast composed of. Choriocarcinoma. Choriocarcinoma is a fast-growing cancer that occurs in a woman's uterus (womb). The abnormal cells start in the tissue that would normally become the placenta. This is the organ that develops during pregnancy to feed the fetus. Choriocarcinoma is a type of gestational trophoblastic disease

Trophoblast - Embryolog

A molar pregnancy, also known as gestational trophoblastic disease, occurs when the tissue that was supposed to form the placenta grows abnormally and can form a tumor that can spread beyond the womb or uterus. In a complete mole, no normal fetal tissue forms. In a partial mole, incomplete fetal tissues develop alongside molar tissue Primitive connective tissue soon lines the interior of the blastocyst wall, and this complex of trophoblast and connective tissue is then named the chorion. Connective tissue promptly grows into the trophoblastic strands, and blood vessels develop in the tissue. The result is the production of many chorionic villi, each resembling a tiny.

About persistent trophoblastic disease and choriocarcinoma

GTD is a heterogeneous group of conditions characterised by abnormal proliferation of trophoblastic tissue.15 24 Risk factors for GTD seem to be related to hormonal factors, since extremes of maternal age, women with poor menstrual flow, menarche after 12 years of age or a prior use of oral contraceptive are at increased risk.5 11 13 PSTT. Achiron R, Goldenberg M, Lipitz S, Mashiach S. Transvaginal duplex Doppler ultrasonography in bleeding patients suspected of having residual trophoblastic tissue. Obstet Gynecol 1993; 81:507-511. Kohorn EI. Evaluation of the criteria used to make the diagnosis of nonmetastatic gestational trophoblastic neoplasia. Gynecol Oncol 1993; 48:139-147 Trophoblastic tissue can persist in the affected tube as well as in implants in the peritoneal cavity. We report an unusual case of a woman who had severe intra-abdominal bleeding after conservative laparoscopic treatment of an EP. This case illustrates the importance of postoperative clinical and hormonal follow-up for early detection of. Synonyms for trophoblastic in Free Thesaurus. Antonyms for trophoblastic. 4 words related to trophoblast: blastosphere, blastula, tissue layer, membrane. What are synonyms for trophoblastic form moles, the trophoblastic tissue persists and causes persistent/invasive mole or choriocarcinoma. Partial mole In partial mole, two sperm cells fertilize a normal ovum resulting in a 69XYY, XXX or XXY chromo some pattern. Often a fetus or fetal tissue is present. Only 0.5-2% of partial moles develop into invasive moles1. INCIDENC

WebpathologyPathology Outlines - Invasive hydatidiform mole

A case study of a 38-year-old woman with a diagnosis of placental site trophoblastic tumor is presented. The patient had a 22-month history of amenorrhea since her last pregnancy, and a dilation and curettage procedure was performed after a 3.1×2.4×2.8 cm endometrial echogenic lesion was visualized on a pelvic ultrasound. When the diagnosis of placental site trophoblastic tumor was made by. The histologic features are most consistent with gestational trophoblastic disease (GTD), complete molar (CM) type. Classical GTD-CM presents in late first or early second trimester of pregnancy (8-18 weeks) with vaginal bleeding and an enlarged uterus for dates. Patients often present with intractable nausea and vomiting (hyperemesis gravidarum) Gestational trophoblastic disease (GTD), or abnormal proliferation of placental trophoblastic tissue, is a rare complication of pregnancy. There is considerable variation in the worldwide distribution of GTD, with the highest frequencies reported in Asia and the Middle East and lower rates on the order of 1 per 1,000 pregnancies i 1 Gestational trophoblastic disease (GTD) consists of a spectrum of disorders that are characterized by an abnormal proliferation of trophoblastic tissue. They include hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT). The incidence of molar pregnancies in Asian countries is 7 to 10 times greater. Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions arising from placental tissue. Epithelioid trophoblastic tumor (ETT), derived from chorionic-type trophoblast, is the rarest form of GTD with only approximately 130 cases described in the literature