Home

Villitis of unknown etiology Pathology outlines

Placenta - Villitis of unknown etiology (VUE) Tell pathologists your words of wisdom through your free Directory listing, click here and get a personalized webpage Villitis of unknown etiology Villitis of unknown etiology, abbreviated VUE, is rare recurrent pathology of the placenta Introduction: Chronic villitis of unknown etiology (VUE) is a chronic inflammatory lesion of third trimester placenta, which contributes to major adverse obstetric outcomes. However, the inciting factors and mechanisms by which VUE contributes to adverse outcomes are poorly understood. This limits our ability to develop preventions or interventions

Villitis of unknown etiology Summary Villitis of unknown etiology (VUE) is an important pattern of placental injury occurring predominantly in term placentas. Although overlapping with infectious villitis, its clinical and histologic characteristics are distinct. It is a common lesion, affecting 5% to 15% of all placentas. When low-grad Objectives: We aimed to determine the association of villitis of unknown etiology (VUE) in complicated and uncomplicated pregnancies. Methods: Placentas from term pregnancies (≥37 weeks) were sent to histopathology evaluation. Maternal and labor characteristics and pathological reports were compared between placentas with VUE (VUE group) and without VUE (controls) Villitis of unknown etiology (VUE) and chronic deciduitis with plasma cells (CD) are supposed to be non infectious placental lesions caused by a pathologic immune reaction similar to a host versus graft mechanism Villitis of unknown etiology (VUE) is an important pattern of placental injury occurring predominantly in term placentas. Although overlapping with infectious villitis, its clinical and histologic characteristics are distinct. It is a common lesion, affecting 5% to 15% of all placentas

Pathology Outlines - Villitis of unknown etiolog

Villitis of unknown etiology (VUE) is an inflammatory condition reported to occur in up to 15% of term placentas. It has been reported in association with fetal growth restriction and antepartum stillbirth. This study aimed to investigate the strength of these associations by completing a systematic review usin A-E: abortion subtypes accessory lobe / bilobate placenta acute chorionic vasculitis & chorioamnionitis acute villitis and intervillositis amnion nodosum amnionic web and amniotic band syndrome anatomy & histology-placenta & umbilical cord blighted ovum chorangioma chorangiomatosis chorangiosis choriocarcinoma chorionic cysts chronic deciduitis. Villitis of unknown etiology (VUE) is noninfectious chronic villitis thought to be associated with fetal growth restriction and stillbirth. COVID-19 and the pandemic SARS-CoV-2 infection can cause an increased risk in pregnant women for potential maternal and fetal complications from an immunological mechanism

Villitis of unknown etiology - Libre Patholog

Villitis of Unknown Etiology (VUE) is a type of inflammation of the placental villi, which occurs due to unknown reasons. In most cases, the inflammation occurs in a term placenta. VUE is seen in 5-15% of the placentas. The placenta is an organ that connects the developing fetus to the uterine wall. It is a disc shaped reddish brown structure. Villitis of unknown etiology (VUE) is a diagnosis of exclusion, requiring first that infectious causes be ruled out adequately 1, 4 - 11. VUE is far more common than its infectious counterpart 1, 10, 12 - 17 and the two present differently: in cases of the latter, usually there are signs and symptoms of infection in the mother or fetus/neonate 1 INTRODUCTION: Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic characteristics Introduction: Chronic villitis of unknown etiology (VUE) is a chronic inflammatory lesion of the placenta. VUE is hypothesized to result from an alloimmune response or as response to an unidentified infection. Lack of a seasonal trend is thought to support VUE as an alloimmune response, though data on seasonal VUE trends are limited To assess the incidence, diagnosis, pathogenesis, and clinical and placental associations of congenital cytomegalovirus infection, 34 cases thereof diagnosed by placental/fetal or neonatal workup (group 1), and 494 placentas with villitis of unknown etiology (group 2) were extracted from a 6083-case placental database. 28 clinical and 47 placental phenotypes were compared between the two.

Background: The objectives of this study are to analyze the frequency and the histopathological features of the villitis of unknown etiology (VUE) in placentas of pregnancies with hypertensive disorders and of small-for-gestational-age infants (SGA) Characterization of inflammation in syphilitic villitis and in villitis of unknown etiology. Kapur P (1), Rakheja D, Gomez AM, Sheffield J, Sanchez P, Rogers BB. (1)Department of Pathology, The University of Texas Southwestern Medical School, Dallas, TX, USA. Chronic villitis is a histologic diagnosis that may be either associated with. Chronic villitis of unknown etiology is a placental abnormality that often coexists with hemorrhagic endovasculitis, a lesion which was associated with stillborn infants in 64.3% of cases and with a recurrence rate of 28.9% in a series of 97 women collected by Sander et al. [15]. Higher rates of recurrence were found with progressively. Villitis of unknown etiology (VUE) is an enigmatic inflammatory condition of the placenta associated with fetal growth restriction and stillbirth. Greater understanding of this condition is essential to understand its contribution to adverse outcomes. Our aim was to identify and quantify the cells in VUE in cases of stillbirth and to.

Chronic villitis of unknown etiology: Investigations into

  1. N2 - Introduction: Chronic villitis of unknown etiology (VUE) is a chronic inflammatory lesion of third trimester placenta, which contributes to major adverse obstetric outcomes. However, the inciting factors and mechanisms by which VUE contributes to adverse outcomes are poorly understood
  2. 1. Introduction. Villitis of unknown etiology (VUE) is one of the most common, inflammatory placental lesions , .Albeit visualized at any gestation, its incidence is higher at term .Histologically, VUE is characterized by an inflammatory cell infiltrate, containing Höfbauer cells (placental macrophages) and T-cell lymphocytes within the placental villi, in the absence of an infective.
  3. Immunohistochemical analysis reveals an influx of regulatory T cells and focal trophoblastic STAT-1 phosphorylation in chronic villitis of unknown etiology. Pediatr Dev Pathol 2011;14:284-93. Redline RW, Patterson P. Villitis of unknown etiology is associated with major infiltration of fetal tissue by maternal inflammatory cells [see comments]
  4. Villitis of unknown etiology (VUE) represents a common placental inflammatory lesion, primarily, but not exclusively, identifiable T lymphocytes at term. Despite considerable evidence to contest that this simply represents a benign pathological finding, VUE remains a significantly undervalued diagnosis. Given its association with adverse pregnancy outcomes; including fetal growth restriction.
  5. they are mostly diagnosed as villitis of unknown etiology (VUE). Autopsy data are useful for the clarification of infectious pathology in stillborn cases. Key words: Intrauterine infection, Chorioamnionitis, Villitis of unknown etiology (Endocrine Journal 41(Suppl): S135—S140, 1994
  6. placental infectiOus villitis versus villitis Of unknOwn etiOlOgy Jerzy Stanek Division of Pathology, Cincinnati Children's Hospital, Cincinnati, USA To assess the incidence, diagnosis, pathogenesis, and clinical and placental asso-ciations of congenital cytomegalovirus infection, 34 cases thereof diagnosed b

Villitis of unknown aetiology (VUA) is associated with adverse pregnancy outcome. Consequently, an ability to predict recurrence could be clinically relevant. We examined placentas where villitis was diagnosed in a previous pregnancy to establish the risk of recurrence and outcome Villitis of unknown etiology (VUE) and chronic deciduitis with plasma cells (CD) are supposed to be non infectious placental lesions caused by a pathologic immune reaction similar to a host versus graft mechanism. In some investigations, infection of human trophoblastic cells with human papilloma virus (HPV) has been described, and a relationship with miscarriage, preeclampsia, and chronic. Characterizing Villitis of Unknown Etiology and Inflammation in Stillbirth. American Journal of Pathology, 186(4), 952-961. JO - American Journal of Pathology. JF - American Journal of Pathology. SN - 0002-9440. IS - 4. ER - Derricott H, Jones RL, Greenwood SL, Batra G, Evans MJ, Heazell AEP 7. Chan JS. Villitis of unknown etiology and massive chronic intervillositis. Surg Pathol Clin 2013; 6: 115-126. 8. Nowak C, Joubert M, Jossic F, et al. Perinatal prognosis of pregnancies complicated by placental chronic villitis or intervillositis of unknown etiology and combined lesions: About a series of 178 cases. Placenta 2016; 44: 104-108. 9 Qiao's Pathology (Art and Science in Medicine) By: Qiao's Pathology (Art and Science in Medicine) Follow. Friend Family Unfollow; Qiao's Pathology: Villitis of Unknown Etiology. Placenta. Microscopic photo: Placenta parenchyma with hyalinized villi that have reduced vasculature and infiltration of lymphocytes and macrophages. H & E Stain

Finding of a single discrete focus of avascular villi suggests involution rather than causative pathology . Villitis of unknown etiology (VUE) with stem villitis and avascular villi (obliterative fetal vasculopathy) is regarded as a distinct process where the primary pathology relates to inflammation and damage of the vessel wall (see text below) Chronic histiocytic intervillositis has been suggested to be along the spectrum of the more recognized lesion known as villitis of unknown etiology,5 along with massive perivillous fibrin deposition and maternal floor infarction.6 Increased perivillous fibrin is often seen in association with CHI.7 The incidence of chronic villitis of unknown.

Elizabeth Ann L. Enninga, Ph.D., an immunologist at Mayo Clinic's campus in Rochester, Minnesota, is studying villitis of unknown etiology (VUE), a placental condition that is inflammatory, not infectious like cytomegalovirus, Toxoplasma gondii or HIV.Findings from the study were published in The Journal of Immunology in April 2020 Explore this photo album by Qiao's Pathology (Art and Science in Medicine) on Flickr Chronic villitis is a histologic diagnosis that may be either associated with infection, or termed villitis of undetermined etiology (VUE). The lymphocytic infiltrate in VUE has been reported to consist of maternal lymphocytes, but the origin of the lymphocytic infiltrate in infectious villitis has not been identified The conjoint immunohistochemistry-in situ hybridization (IHC-ISH) procedure permits, under routine light microscopic conditions, simultaneous documentation of either a male or female karyotype plus the immunological phenotype of individual cells within paraffin-embedded tissues. We have used this technique to characterize the inflammatory response in placental villitis of unknown etiology (VUE)

The histopathology of villitis of unknown aetiology. Placenta 1980; 1:227. Knox WF, Fox H. Villitis of unknown aetiology: its incidence and significance in placentae from a British population. Placenta 1984; 5:395. Redline RW, Patterson P. Villitis of unknown etiology is associated with major infiltration of fetal tissue by maternal. N2 - Villitis of unknown etiology (VUE) is an enigmatic inflammatory condition of the placenta associated with fetal growth restriction and stillbirth. Greater understanding of this condition is essential to understand its contribution to adverse outcomes

Villitis of unknown etiology - prevalence and clinical

  1. We performed in situ hybridization studies with BKV probes on cases of villitis of unknown etiology (102), diffuse villitis (25), and spontaneous abortion (22). We found no evidence that BKV plays a role in the pathogenesis of these common fetoplacental disorders
  2. Director of Perinatal Pathology Department of Pathology University of California San Diego. Outline n IUGR: definition(s) n Causes of IUGR n Focus on placenta n Implications for future pregnancies. Outline n IUGR: Villitis (chronic villitis of unknown etiology/CVUE) n Unremarkable prenatal cours
  3. Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, et al. Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental.
  4. Perinatal prognosis of pregnancies complicated by placental chronic villitis or intervillositis of unknown etiology and combined lesions: About a series of 178 cases. Nowak C, Joubert M, Jossic F, Masseau A, Hamidou M, Philippe HJ, Le Vaillant C. Placenta, 44:104-108, 15 May 201
  5. The topic Noninfectious Chronic Villitis of Placenta you are seeking is a synonym, or alternative name, or is closely related to the medical condition Villitis of Unknown Etiology. Quick Summary: Villitis of Unknown Etiology (VUE) is a type of inflammation of the placental villi, which occurs due to unknown reasons
  6. Placenta pathology associated with maturation abnormalities and late intra uterine foetal death. Peter G.J. Nikkels, Dept. of Pathology UMC Utrecht, the Netherlands. The placenta is the fastest growing organ of the human body. The placenta grows from with chronic villitis of unknown etiology (VUE)

Villitis of unknown etiology and chronic deciduitis are

Placental Pathology: Atlas of Non-tumor Pathology Villitis of unknown etiology: noninfectious chronic villitis in the placenta. Hum Pathol 2007; 38: 1439-46. 15. Bulmer, JN, Smith, J, Morrison, L, Wells, M. Maternal and fetal cellular relationships in the human placental basal plate Fig. 2 Histopathology of chronic deciduitis with plasma cells: Plasma cells and an increased density of lymphocytes in the decidua basalis are visible (hematoxylin and eosin, magnification is 400) - Villitis of unknown etiology and chronic deciduitis are not associated with human papilloma virus and enterovirus infectio The etiology of chronic villitis is not fully elucidated yet. Some cases can be attributed to infections with microorganisms like cytomegalovirus or Treponema pallidum. A large proportion of cases of chronic villitis however were classified as villitis of unknown etiology (VUE) and may reflect a noninfectious immune response Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles.Here are links to possibly useful sources of information about Villitis of unknown etiology.. PubMed provides review articles from the past five years (limit to free review articles); The TRIP database provides clinical publications about.

What are the Causes, both Infectious and Non-Infectious, of These Changes? What Further Workup is Warranted in This Case? 15 Case 3. Diagnosis Villitis of Unknown Etiology (VUE) 16 Case 3. Villitis of Unknown Etiology (VUE) Association With Intrauterine Growth Retardation, Stillbirths, and Premature Birth ; Perhaps up to 10 of Placentas in. • Chronic villitis→Histiocytes with some lymphocytes and plasma cells→associated with either TORCH infections (so get CMV and Syphilis stains) or immune-mediated Villitis of Unknown Etiology • Diffuse Stromal Edema →look for clear, watery, hypocellular stroma →often caused by fetal hydrop Villitis of unknown etiology: noninfectious chronic villitis in the placenta. Hum Pathol 2007; 38:1439. Harteman JC, Nikkels PG, Benders MJ, et al. Placental pathology in full-term infants with hypoxic-ischemic neonatal encephalopathy and association with magnetic resonance imaging pattern of brain injury Demonstration of villitis of unknown etiology as a unique condition that presents the combined features of maternal anti-fetal rejection and graft-versus-host disease Determination of the association between the failure of physiological transformation of the spiral arteries and a subset of spontaneous preterm labor and birt

Pathology Outlines - Chorioamnionitis

Villitis of unknown etiology: noninfectious chronic

Background: Chronic villitis (CV) has been regarded as the hallmark lesion of the ToRCH entities and is also more common in women with other auto and/or all-immune pathology. CV has been linked to maternal and neonatal pathology, but reports are confined only to placentas with some indication for pathology examination. What are the associations of CV in a population based sample from.. Boog G, Le Vaillant C, Alnoukari F, Jossic F, Barrier J, Muller J-Y. Combining corticosteroid and aspirin for the prevention of recurrent villitis or intervillositis of unknown etiology. J Gynecol Obstet Biol Reprod (Paris) 2006;35(4):396-404. doi: 10.1016/s0368-2315(06)76411-. Search PubMe All authors jointly agreed upon the outline of the article. T.Y.K. wrote the draft, and all authors contributed in the revision and finalization of the manuscript. which is similar histologically to the vascular lesion seen in allograft rejections, 4 while villitis of unknown etiology A prospective collection of placental pathology data. Villitis is characterized by the presence of inflammatory infiltrate (CD8 lymphocyte) in the placental villous and is classified as to the etiology in known and unknown. In most cases, villitis is idiopathic (villitis of unknown etiology [VUE]) because no microorganisms are evident and there are no maternal symptoms or signs

ETIOLOGY, PATHOLOGY AND PATHOGENESIS OF CORNEAL ULCERPathology Outlines - Placenta

Investigating the association of villitis of unknown

Start studying Placental Pathology (Test 2). Learn vocabulary, terms, and more with flashcards, games, and other study tools These cases were labelled 'unexplained with placental lesion of unknown significance' (Figure 4) and included abnormalities such as isolated subjective increased syncytial knots/accelerated maturation, villitis of unknown etiology, scattered intervillous thrombi, focal areas of sclerotic villi with no other features of fetal thrombotic.

Etiology/Pathology | Amyotrophic Lateral Sclerosis

Pathology Outlines - Placent

Application of an organ transplant rejection test offers insight into understanding preterm births and recurrent miscarriages. This recent study in the January/February issue of Pediatric and Developmental Pathology provides evidence that, like a transplant recipient's body can reject a donor organ, chronic villitis of unknown etiology (VUE) can cause the mother's body to reject her fetus Department of Pathology and Laboratory Medicine. 8700 Beverly Blvd., Room 8709. Los Angeles, CA 90048-1804. 310-423-6941. send a message. October 2019 Case Education Graduate Medical Education Residency Programs Anatomic and Clinical Pathology Residency Case of the Month Archive October 2019 Case

PPT - Valvular Heart Disease PowerPoint Presentation, freePostulating a new concept of the etiology, pathology and

Human Pathology 1998;29(12):1457-61. 29. Jacques SM, Qureshi F. Chronic intervillositis of the placenta. Archives of Pathology & Laboratory Medicine 1993;117(10):1032-5. 30. Chan JS. Villitis of Unknown Etiology and Massive Chronic Intervillositis. Surgical Pathology Clinics 2013;6(1):115-26. 31. Boyd TK, Redline RW Understanding the fundamental histopathology of chorionic villitis, intervillositis, and chorionic vascular thrombi, known as fetal thrombotic vasculopathy, can enable neonatologists to interpret placental pathology reports. In addition, such understanding helps them to provide parents with explanations about their infants' conditions, short- and long-term prognoses, and risk factors for. Villitis of unknown etiology (chronic villitis): chronic villitis is occasionally due to an infectious etiology, but this is uncommon, and specific associations will be mentioned in the section discussing infection. This section will focus on the much more common Villitis of Unknown Etiology (VUE). villous outlines with complete loss of.