Oxazepam and temazepam together

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Völlig natürlich habe ich meine Schlafstörungen behoben Gratis Versand in 24 Stunden bereits ab 20 €. Erleben Sie günstige Preise und viele kostenlose Extras wie Proben & Zeitschriften We would like to show you a description here but the site won't allow us oxazepam oral and temazepam oral oxazepam oral and temazepam oral both increase sedation and drowsiness. Patient Drug Interactions Source: RxList © 2021 RxList, Inc

The phase IV clinical study analyzes what interactions people who take Oxazepam and Temazepam have. It is created by eHealthMe based on reports of 1,521 people who take Oxazepam and Temazepam from the FDA, and is updated regularly Both Oxazepam and temazepam belong to a group of drugs called benzodiazepines. Benzodiazepines are usually prescribed as a sedative or to relieve anxiety. They are a depressant, which means they help slow the body's system down and have sleep inducing properties. Both drugs are similar in their duration of action and side effects etc

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Temazepam is a fairly minor diazepam metabolite (you could call temazepam hydroxy-diazepam). Temazepam and its major metabolite, oxazepam are eliminated fairly quickly (say 5-8 day to a negative drug screen) Nordiazepam and temazepam are then further metabolized to the final active metabolic product oxazepam. Thus, the presence of nordiazepam, temazepam, and oxazepam together on a UDS is consistent with diazepam use Safe is a relative word. To imagine someone being on all those meds together is scary at 1st, but some patients require lots of high dose meds to function. My main concern is the use of 3 different benzos at the same time (diazepam, oxazepam, and temazepam). I have several patients on 2 benzos...and only rarely one on 3 Because the exact drug ingested may not be distinguishable due to the overlapping metabolic pathways, positive results for Nordiazepam, Oxazepam, and/or Temazepam are reported by Aegis as Benzodiazepine Metabolites. Some commonly prescribed benzodiazepines have unique metabolites, which make identification more straightforward Comparing benzodiazepines. This page has information to help you compare different benzodiazepines. It has tables for comparing benzodiazpines mainly used for anxiety, and for comparing benzodiazepines mainly used for insomnia (difficulty getting to sleep or staying asleep).. It also has information explaining how benzodiazepines differ from each other

Oxazepam with Temazepam 1764-0 Drug Interactions - Drugs

Using Suboxone and benzodiazepines together exacerbates central nervous system depression. Side effects of mixing these drugs may include: Deep sedation. Lowered blood pressure. Respiratory depression. Coma. Death. Combining these drugs can make a person very drowsy with significantly slow reaction times, which can lead to accidents Oxazepam and temazepam (Bufa BV, The Netherlands) were dissolved in 10% (v/v) solutol (a polyoxyethylene ester of 12-hydroxystearic acid) and ultrapurified water and administered (s.c.) at a dose of 0.3 mg/kg each. In the control experiments where compounds were administered individually, the appropriate vehicle control for the combination was. Prozac, propranolol and diazepam or temazepam can be taken together but a small consideration has to be done that each of them increase the effects of each other (this is considered as moderate drug interaction). will temazepam and oxazepam show up as the same thing in a random drug screen,. Lorazepam and temazepam are both benzodiazepines. Temazepam is more sedating and used for insomnia Alcohol and antidepressants are among the drugs that can potentially cause drug interactions with oxazepam. This eMedTV page describes how oxazepam interactions can raise your risk of side effects like drowsiness, confusion, or difficulty breathing

oxazepam oral and temazepam oral Drug Interactions - RxLis

  1. oclonazepam, hydroxyl-ethyl-flurazepam, lorazepam, nordiazepam, oxazepam, and temazepam
  2. Intended for use when interchanging benzodiazepines and should not be used to help calculate an initial dose for a benzodiazepine naïve patient. Very short acting: <6 hours. Short acting: 6-12 hours (ALPRAZolam, oxazepam, triazolam). Intermediate acting: 12-24 hours (LORazepam, temazepam). Long acting: >24 hours (chlordiazePOXIDE, diazePAM.
  3. The diazepam, nordiazepam, temazepam, and oxazepam detection limits were found to be 20, 20, 30, and 35 ng ml −1 in heparinized blood, respectively. 34 Automation of the SPME device has also been achieved for extraction of benzodiazepines from whole blood using three different types of extraction phases for comparison: PDMS-based, C18-coated.
  4. Oxazepam is a short-to-intermediate-acting benzodiazepine. Oxazepam is used for the treatment of anxiety and insomnia and in the control of symptoms of alcohol withdrawal syndrome.. It is a metabolite of diazepam, prazepam, and temazepam, and has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties compared to other benzodiazepines
  5. the study above says that temazepam's fatal toxicity index (which is 11.9) is higher than many tricyclic antidepressants. oxazepam is the least sedating and the least toxic benzo (fatal index of 2.3). the average fatal toxicity index for most benzos as a whole is 5.7. So temazepam is significantly more toxic than most benzos
  6. The phase IV clinical study analyzes what interactions people who take Aleve and Temazepam have. It is created by eHealthMe based on reports of 246 people who take Aleve and Temazepam from the FDA, and is updated regularly. With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug.

Oxazepam and Temazepam drug interactions, a phase IV

  1. A specially designed sleep questionnaire was used to assess the performance of the two hypnotic drugs. Psychiatric patients were given 5 mg nitrazepam or 10 mg temazepam in identical capsules, and were allowed more if necessary. A double-blind cross-over design was used. We found that 5-2 mg nitraze
  2. However, use of these glucuronyl transferase substrates (e.g., lorazepam, oxazepam, and temazepam) with that enzyme's inducer, ritonavir, can require higher doses of benzodiazepines. 20, 130 The NNRTIs efavirenz and nevirapine, along with the PI ritonavir, have the potential to induce the 3A isoenzymes. This 3A induction may be delayed and.
  3. Diazepam is metabolized extensively into active metabolites including desmethyldiazepam, temazepam, and oxazepam. Because of this, diazepam has a half-life of 30 to 60 hours. Summary. Caution is necessary when taking oxycodone and Valium together due to the increased risk of sedation, CNS depression, and respiratory depression

Temazepam also increases total sleep time and is used to treat insomnia. It is a benzodiazepine, the same class of drugs as diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), flurazepam (Dalmane), and lorazepam (Ativan). Temazepam and other benzodiazepines act by enhancing the effects of the neurotransmitter gamma-aminobutyric acid. The interaction between metoprolol and bromazepam and lorazepam was studied in 12 healthy male volunteers aged 21-37 years. Metoprolol had no significant effect on the pharmacokinetics of bromazepam or lorazepam. However, bromazepam AUC was 35% higher in the presence of metoprolol. Bromazepam enhanced the effect of metoprolol on systolic blood pressure but not on diastolic blood pressure or. Temazepam is classed as a 1,4 benzodiazepine, with the chemical name 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1-4-benzodiazepin-2-one. It's structurally most closely related to diazepam and oxazepam. In its pharmacological properties however, temazepam is most closely related to nimetazepam, nitrazepam, and flunitrazepam

temazepam and oxazepam together making up nearly 4% of all prescriptions written by general practitioners.3 Use increases with age4 and there is a high prevalence of chronic benzodiazepine use in the elderly.5 A Swedish study of data from a population prescription registry found that among new benzodiazepine users 10% had continue oxazepam or temazepam on the SSRI paroxetine-induced 5-HT increase in the hippocampus of freely moving guinea-pigs. Paroxetine was chosen for this study since it is a widely used and very potent SSRI (Mertens & Pintens, 1988). Oxazepam and temazepam represent the newest generation of benzodiazepines

What is the difference between oxazepam and temazepam

  1. Aroclor 1254 and dexamethasone had the strongest inducing effect on temazepam and the second strongest on oxazepam. The strong and overlapping inductive role of phenobarbital strengthens the participation of CYP2B6 and CYP3A in diazepam N-demethylation and CYP3A in temazepam formation
  2. Possibility of combination of omeprazole, clonazepam showing a false-positive for temazepam or oxazepam in urine drug test? MD. Is it possible that a combination of proton-pump inhibitor ( omeprazole ) and clonazepam could show as a false-positive for temazepam or oxazepam in urine drug test
  3. Temazepam: Was 40mg every night, but I've been taking 30 now as per the doctors orders Oxazepam: 15-30mg for the anxiety and panic attacks, when needed. I've been taking them quite frequently, but not daily. More like every few days. Ketipinor: 25-75mg per night if I can't sleep, but like I said, I'm not going to use them anymore
  4. A person struggling with oxazepam abuse may empty the capsule and snort the contents. When a person snorts Serax, they are usually trying to amplify the drug's sedative effects. Unfortunately, oxazepam comes with a list of uncomfortable side effects. Snorting oxazepam could cause a person to experience these impacts more severely
  5. How much Temazepam is required to kill myself? I am currently on 40mg nightly to help, anti-psychotics, SSRI's and Benzo's. I have about 100+ Temazepam 40mg tablets. Would taking all of them do the job? I always thought suicide was a cry for help but the NHS doesn't hear me shouting. I know it will hurt others around me but I figure me livin
  6. Oxazepam 10mg 15mg 15mg (10-40mg) 15mg 10mg Temazepam 10mg 10mg 10mg 10mg 10mg a. Inter-patient variability and differing half-lives mean the figures can never be exact and should be interpreted using clinical and pharmaceutical knowledge. b. These equivalents do not agree with those used by some authors. They are firmly base
Determination of Drugs of Abuse: GERSTEL DPX

oxazepam (Serax) temazepam (Restoril) triazolam (Halcion) quazepam (Doral) People who had taken a benzodiazepine for three months or less had about the same dementia risk as those who had never taken one. Taking the drug for three to six months raised the risk of developing Alzheimer's by 32%, and taking it for more than six months boosted. There are countless deaths attributed to temazepam overdose alone, without mixing it with alcohol or other CNS depressants. the study above says that temazepam's fatal toxicity index (which is 11.9) is higher than many tricyclic antidepressants. oxazepam is the least sedating and the least toxic benzo (fatal index of 2.3)

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What are the dangers of taking Diazepam and Temazepam

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L - Lorazepam. O - Oxazepam. T - Temazepam. These do not have active metabolites, and the half-life remains relatively the same even in the setting of liver disease. The rest of the benzodiazepines are primarily metabolized via hepatic CYP-mediated oxidation. These may have prolonged duration of effect in patients with marked liver. Oxazepam is a benzodiazepine used extensively since the 1960s for the treatment of anxiety and insomnia and in the control of symptoms of alcohol withdrawal. It is a metabolite of diazepam, prazepam and temazepam, among the benzodiazepines considered in this volume The amount of time a benzodiazepine remains in your system partly depends on what type it is: ultra-short, short, intermediate, or long-acting. 3 . Ultra-short benzodiazepines have a half-life of fewer than five hours, while short- to intermediate-acting benzodiazepines like Restoril have a half-life from five to 24 hours

Meanwhile, diazepam together with the me- tabolites (nordazepam, oxazepam, and temazepam) determi- nation in hair have also been reported [2, 10-12, 15, 17-19] To lower your risk, your doctor should have you take the smallest dose of oxazepam that works, and take it for the shortest possible time. Get medical help right away if any of these very serious. Of the 13 benzodiazepines included in the study, we detected 9, which together showed median and mean concentrations (of the results above limit of quantification) of 5.4 and 9.6 ng L-1, respectively. Four benzodiazepines (oxazepam, temazepam, clobazam, and bromazepam) were the most commonly detected

Demystifying Benzodiazepine Urine Drug Screen Result

  1. Temazepam belongs to a group of medicines called benzodiazepines. It's used to treat sleeping problems (insomnia). It can also be taken to help you relax before an operation or other medical or dental treatments. This is known as a pre-med. It comes as tablets or as a liquid that you swallow
  2. Oxazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat anxiety disorders. Oxazepam may also be used short-term to treat symptoms of alcohol withdrawal
  3. In vitro interaction of diazepam and oxazepam with pancuronium and suxamethonium. Driessen JJ, Vree TB, van Egmond J, Booij LH, Crul JF. In vitro studies using the rat phrenic nerve-hemidiaphragm preparation were performed to investigate the effects of diazepam and three of its metabolites on indirectly evoked twitch tension
  4. excessive saliva production. dry mouth. stomatitis, a condition with painful swelling and sores inside the mouth. a painful, red or swollen tongue. constipation. a problem with menstrual periods.
  5. obutyric acid by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into.
  6. Br. J. clin. Pharmac. (1979), 8, 57S-61S DIAZEPAMANDITSHYDROXYLATED METABOLITES:STUDIESONSLEEPIN HEALTHYMAN BARBARAM.STONE RoyalAir ForceInstituteofAviation Medicine, Farnborough, Hampshire, UK 1 Theeffects ofdiazepam 5, 10 and 15 mgand its hydroxylated metabolites, 3-hydroxydiazepam (temazepam) 10, 20 and 30 mg and 3-hydroxy, N-desmethyldiazepam (oxazepam) 15, 30 an
  7. obutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors 6,7,13,14

Dec 10, 2004. Which one is the strongest depends on your tolerance and how much you take. Valiums and Klonopins relax me and make me feel calm, but I wouldn't call them strong drugs. Xanax, if you take enough can be much stronger, imo, than the other two. It can make you much more drowsy. -K. Dec 11, 2004 #7 Many psychiatric and medical disorders present with symptoms of insomnia and associated daytime impairment.It is essential to first identify such disorders if present (e.g. depression, chronic anxiety or obstructive sleep apnea) so that they can be treated specifically How much Temazepam does blood reading of 0.14 mg/kg of Oxazepam indicate? MD A Blood reading of 0.14 mg/kg of Oxazepam and a urine reading of >5100 ug/l Oxazepam would equate to how many Temazepam 10mg tablets being taken?.

Background: A fast and sensitive assay for quantifying total and unbound concentrations of lorazepam (Lzp), oxazepam (Ozp) and temazepam (Tzp) in human plasma was needed for a plasma protein binding study.Results: Plasma samples were precipitated with acetonitrile for determination of total concentrations or subjected to ultrafiltration for determination of unbound concentrations While your doctor should provide the ultimate advice, it likely is okay to take Xanax and Zoloft together. The reason is because Xanax and Zoloft work on different pathways in the brain. For example, Xanax suppresses and calms central nervous system activity, and SSRIs like Zoloft are designed to regulate serotonin levels Contact. Temazepam (Restoril®) January 1, 2021. S elected References: Ban L, et al. 2014. First trimester exposure to anxiolytic and hypnotic drugs and the risks of major congenital anomalies: a United Kingdom population-based cohort study. PLoS One; 9 (6):e100996. Dusci LJ, et al. 1990. Excretion of diazepam and its metabolites in human milk.

Are these medications safe while being used together

Lorazepam 1mg Nitrazepam 5mg Oxazepam 15mg Temazepam 10mg Loprazolam 1mg Lormetazepam 0.5mg - 1.0mg... Prescription drugs and DUI? Baclophen, 3mg of Klonopin, 10mg of Lexapro and 30mg of Temazepam.in one day Oxazepam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. Tell your doctor if you are taking or plan to take certain opiate medications for cough such as codeine (in Triacin-C, in Tuzistra XR) or hydrocodone (in Anexsia, in Norco, in Zyfrel) or for pain such as codeine (in Fiorinal), fentanyl (Actiq, Duragesic. Diazepam is metabolized extensively into active metabolites including desmethyldiazepam, temazepam, and oxazepam. Because of this, diazepam has a half-life of 30 to 60 hours. Use for sleep is not recommended in elderly patients due to the long half life and risk of increased side effects such as falling. Information About Diphenhydramin

What Did My Patient Actually Take? An Overview of

Oxazepam is an orally available benzodiazepine used in the therapy of anxiety and acute alcohol withdrawal syndromes. As with most benzodiazepines, oxazepam therapy has not been associated with serum aminotransferase or alkaline phosphatase elevations, and clinically apparent liver injury from oxazepam has not been reported and must be very rare, if it occurs at all So whats the right mix to end it all, have codeine, Valium, temazepam, alcohol. only about 18*5mg diazepam 18*30mg cod phos. 20* 10mg tamaze plus 15 out of date 10mg temazepam ideas? Don't want vegie state just for it all to en

Comparing benzodiazepines Mind, the mental health

The benzodiazepines diazepam and oxazepam have been found to produce fewer withdrawal reactions than alprazolam, temazepam, or lorazepam. Alprazolam - Wikipedia In patients with an abnormal CYP2C19 variant certain benzodiazepines should be avoided, such as diazepam (Valium), lorazepam (Ativan), oxazepam (Serax), and temazepam (Restoril) What Is Nordiazepam? Nordiazepam is a benzodiazepine and one of three metabolites of diazepam commonly used to treat anxiety, seizures and other medical conditions, according to Practical Pain Management. Diazepam is the generic name for the drug often sold as Valium. Since diazepam is the parent drug, nordiazepam frequently appears on. Temazepam is an intermediate acting benzodiazepine and hypnotic. It works by affecting GABA within the brain. Temazepam was patented in 1962 and came into medical use in 1969. It is available as a generic medication. A month supply in the United Kingdom costs the NHS about £1.40 as of 2019 Temazepam. Temazepam is a white, odourless crystalline powder; it is sparingly soluble in alcohol and freely soluble in chloroform, but insoluble in water. APO-Temazepam (temazepam) is a 1, 4 benzodiazepine with the chemical name 7-chloro-1, 3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1-4-benzodiazepin-2-one The generic name of Restoril is temazepam. Restoril can be prescribed to help someone who has problems falling asleep or who frequently wakes in the night. Like other benzodiazepines, Restoril is meant for short-term use. Restoril isn't meant to be used for more than 7 to 10 days, in most cases. Part of the reason for this limited duration is.

If these medicines are prescribed together, limit the oxazepam No brand name currently marketed quazepam Doral temazepam Restoril triazolam Halcion Other Sleep Drugs and Tranquilizer Oxazepam Serax® 2-3 5-20 hours 15-30 mg Capsule Temazepam Restoril® 0.75-1.5 3.5-20 hours 10-30 mg Capsule Triazolam Halcion® 0.75-2 1.5-5.5 hours 0.25-0.5 mg Table

Combinations - Diazepam and Temazepam Drugs-Foru

Oxazepam and temazepam (Bufa BV, The Netherlands) were dissolved in 10 % (v/v) solutol (a polyoxyethylene ester of 12-hydroxystearic acid) and ultrapurified water and administered (s.c.) at a dose of 0.3 mg/kg each. In the control experiments where compounds were administered individually, the appropriate vehicle control for the combination was. • As expected, Temazepam and Oxazepam glucuronides are present together RESULTS 1. R.C. Baselt. Sample # Oxazepam Oxazepam Glucuronide Temazepam Temazepam Glucuronide Lorazepam Lorazepam Glucuronide 53 20 1304 511 0 190 0 137 11 1990 772 8 714 578 0 158 73 4014 31 521 232 27 4988 82 617. Temazepam (Restoril®) Disulfiram (Antabuse®) - disulfiram may decrease the clearance of temazepam. Consider using another benzodiazepine that has not been shown to interact with disulfiram (alprazolam, oxazepam, lorazepam). [12] Triazolam (Halcion®) CYP3A4 strong inhibitors - DO NOT COMBINE. Triazolam is a CYP3A4 sensitive substrate, and. The log distribution of the fraction of nordiazepam, temazepam and oxazepam from 22,509 specimens from unique subjects approximated a Gaussian distribution (Figure 2). The geometric mean fractions of excreted nordiazepam, temazepam and oxazepam were 0.16, 0.34 and 0.47 (P < 0.00001 for each pairwise comparison). Of the total, 92% of the. Temazepam (minor) Oxazepam (minor) 10-30 days 6,8 Alprazolam 0.5mg 1-2 Hydroxylation CYP 3A4 12-15 hours α-hydroxy-alprazolam 5 days Clonazepam 0.25mg 1-4 Nitroreduction Acetylation CYP 3A4 NAT2 30-40 7-amino-clonazepam 5 days Oxazepam 15mg 2-4 Conjugation UGT2B15 UGT1A9 UGT2B7 5-20 Oxazepam-.

Understanding the Toxicology of Diazepa

nordiazepam, oxazepam, temazepam, cetirizine, metoprolol, promethazine, and ranitidine breakdown.1 Appellant's witness, Dr. Greer, testified that each of the chemical substances found in appellant's urine screen appeared to be from medications he prescribed to appellant or over-the-counter medication oxazepam (Serax) temazepam (Restoril) High-potency Benzodiazepine List. With a long half-life: clonazepam (Klonopin) With a short half-life: alprazolam (Xanax) lorazepam (Ativan) triazolam (Halcion) Though not prescribed in the United States, flunitrazepam (Rohypnol) is sold illicitly on the streets. Used as a date rape drug, Rohypnol is a high. Zopiclone and some benzodiazepines, such as temazepam and triazolam, are indicated for the short-term treatment of insomnia (i.e. four weeks or less). Long-term use of these medicines should be avoided where possible due to adverse effects and the potential for the development of dependence. The objective of the audit is to promote appropriate. Oxazepam Oxcarbazepine Oxycodone Oxymorphone Ozanimod Palbociclib Palonosetron Papaveretum Paregoric Temazepam Terbinafine Thiethylperazine Thiopental Thiopropazate Thioridazine Tianeptine If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol. Diazepam is a prescription medication used to treat anxiety, seizures, muscle spasms, epilepsy, and alcohol withdrawal. Some people mix alcohol and diazepam in an effort to intensify the relaxing effects of alcohol or control the symptoms of alcohol withdrawal without understanding the effects of mixing diazepam and alcohol

Drug Testing: Benzodiazepines - Mayo Clinic Laboratorie

Alternative Agents: Lorazepam Oxazepam Temazepam. Ritonavir 178, 55 (RTV)(Norvir)---Increased diazepam levels: Increased diazepam effects (eg, increased sedation, confusion, respiratory depression) Inhibition of CYP450 3A by ritonavir: Do not coadminister Both nordiazepam and temazepam are further metabolized to oxazepam. Then, the combination of temazepam and oxazepam by glucuronidation and glucuronic acid is largely eliminated. However, they are still biologically active and able to accumulate with continuous application ( St-Pierre et al., 1993 )

The primary care physician is in a good position to diagnose, manage and intervene with patients who are undergoing the process of treatment and recovery from alcohol and drug disorders Chlordiazepoxide, oxazepam, and temazepam are available in capsule form. Diazepam also is available as a rectal gel. Some benzodiazepines are available for injection. Ambien. The recommended adult dose of zolpidem conventional tablets or spray is 5 mg for females, the elderly, or fragile individuals, and 5 to 10 mg for males Temazepam is a known metabolite of Diazepam (Valium) as is Nordiazepam and Oxazepam. This means that Diazepam is broken down by the body into the above stated (3) metabolites. Though Temazepam. Oxazepam, together with triazolam, was included in the 'other benzodiazepines' category in the comprehensive case-control study by Rosenberg et al. (1995) reviewed in detail in the monograph on diazepam (pp. 51 -53). Too few subjects had used oxazepam to allow analysis of this drug as a separate category, but no elevated risk was associate Separation of oxazepam, lorazepam, and temazepam enantiomers by HPLC on a derivatized cyclodextrin-bonded phase: application to the determination of oxazepam in plasma. 2002 Dec 31. 12543505. Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines. Br Med J. 1980 Mar 29;280(6218):910-2. PubMed ID. 7388368 [ View in PubMed] Abstract. Not Available. DrugBank Data that Cites this Articl