Human immunodeficiency virus-associated dementia: clinical aspects, biology, and treatment. Venkataramana A(1), Sacktor N. Author information: (1)Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Department of Nuerology, Baltimore, MD 21224, USA What is HIV associated dementia? When someone has the human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) they may develop a complication to the disease which is known as HIV associated dementia, or as AIDS Dementia Complex (ADC) Human immunodeﬁciency virus-associated dementia: An evolving disease Justin C McArthur, Norman Haughey, Suzanne Gartner, Kathy Conant, Carlos Pardo, Avi Nath, and Ned Sacktor The Johns Hopkins University, HIV Neurology Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, US (2003). Human Immunodeficiency Virus-Associated Dementia: An Evolving Disease. Journal of Neurovirology: Vol. 9, No. 2, pp. 205-221
A human immunodeficiency virus type 1 (HIV)-seropositive, antiretroviral-naive patient presented with significant cognitive dysfunction. Neuropsychologic, neuroradiologic, immunologic, and virologic studies confirmed HIV-associated dementia (HAD) 16. Human Immunodeficiency Virus-Associated Dementia. Another one on the list of the common types of dementia that we would like to reveal in this article today and want all of my readers to know and consider consulting with your doctor in case they are diagnosed to have human immunodeficiency virus- associated dementia
HIV-1 infection is characterized by multiple neurological syndromes occuring at all stages of infection. HIV-1-associated dementia, however, is the most devastating CNS consequence of AIDS because of its poor prognosis and functional impairment McArthur JC, McClernon DR, Cronin MF, et al. Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain [see comments]. Ann Neurol 1997;42(5):689-698 McArthur, JC, et al. Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol 1997. 42 :689-698 Human immunodeficiency virus-associated dementia History of high-risk sexual behavior or drug use, hyporeflexia, papillary abnormalities, decreased proprioception Neurosyphili HIV -associated dementia. This form really limits someone's ability to lead a normal life. People in the later stages can have seizures, psychosis, and loss of bladder or bowel control. All stages.
Delirium and human immunodeficiency virus (HIV)-associated dementia are well recognized neuropsychiatric consequences of HIV infection in adults. Almost nothing is known regarding the management of delirium in HIV-infected children and adolescents Simpson, D.M. (1999) Human immunodeficiency virus-associated dementia Review of pathogenesis, prophylaxis, and treatment studies of zidovudine therapy. Clinical Infectious Disease, 29, 19-34.doi10.1086/52015 HIV-associated vacuolar myelopathy (HIV-VM) is the most common cause of spinal disease in HIV/AIDS. HIV-VM causes progressive spastic paraparesis, sensory ataxia, and autonomic dysfunction. It is a progressive myelopathy that shares features with subacute combined degeneration seen in vitamin B12 deficiency as well as other neurological diseases and can occur synchronously with HIV-associated.
The dementia associated with human immunodeficiency virus (HIV) is poorly understood. Dementia is accompanied by infection and activation of macrophage lineage cells in the brain and production of toxic products by these cells has been postulated to play a role in the pathogenesis of dementia The dementia associated with human immunodeficiency virus (HIV) is poorly understood. Dementia is accompanied by infection and activation of macrophage lineage cells in the brain and production of toxic products by these cells has been postulated to play a role in the pathogenesis of dementia. Eicosanoids are potential products of activated macrophages that can mediate cell injury. We measured.
Acronym Definition; HIVD: Herniated Intervertebral Disc: HIVD: Human Immunodeficiency Virus Disease: HIVD: Human Immunodeficiency Virus Dementia AIDS dementia complex (ADC), also known as HIV encephalopathy, is a neurological disorder directly caused by HIV. It is a condition classified by the Centers for Disease Control and Prevention (CDC) as an AIDS-defining condition and is characterized by the deterioration of cognitive, motor and behavioral function, the symptoms of which can. It is not known whether the apolipoprotein E (ApoE) ε4 allelic variant is associated with human immunodeficiency virus (HIV)-associated dementia (HAD) in a South African population, where HIV clade C is predominant. ApoE genotyping was performed on 144 participants in a larger study of HIV-associated neurocognitive disorders (HAND). There was a lower frequency of the ε2 and ε3 alleles in the..
Dementia and the Neurovirulence of HIV-1 - Volume 5 Issue Injection drug use has been recognized as a major risk factor for acquired immunodeficiency syndrome (AIDS) from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States, can both impair the functions of macrophages and CD4 + lymphocytes and also activate human immunodeficiency virus (HIV)-1 expression in these cells The pathogenesis of human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) is mediated mainly by mononuclear phagocyte (MP) secretory products and their interactions with neural cells. Viral infection and MP immune activation may affect leukocyte entry into the brain. One factor that influences central nervous system (CNS) monocyte migration is matrix metalloproteinases (MMPs. Apolipoprotein-E genotype and human immunodeficiency virus-associated neurocognitive disorder: The modulating effects of older age and disease severit 3′‐Azido‐2′,3′‐dideoxythymidine (AZT) has been administered to 7 patients with human immunodeficiency virus associated neurological disease: 3 with dementia, 2 with peripheral neuropathy, 1 with dementia and peripheral neuropathy, and 1 with T‐10 paraplegia. Six of the patients showed improvement in their neurological dysfunction.
Search for this keyword . Meeting abstracts only . Main men Navia BA,Price RW, The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection. Archives of neurology. 1987 Jan; [PubMed PMID: 3800724
The spatial distributional pattern of neurons, in the superior frontal gyrus of 32 subjects who died of acquired immune deficiency syndrome, was examined. The patients were classified as nondemented, mildly demented, and severely demented, and some were treated with the anti-retroviral drug zidovudine. Spatial statistical techniques were employed to investigate the degree of clustering in the. Krikorian R, Wrobel AJ, Meinecke C, et al. Cognitive deficits associated with human immunodeficiency virus encephalopathy. J Neuropsychiatry Clin Neurosci 1990;2(3):256-60. 4. Clifford DB. Human immunodeficiency virus-associated dementia. Arch Neurol 2000;57(3):321-4. 5 3'-Azido-2',3'-dideoxythymidine (AZT) has been administered to 7 patients with human immunodeficiency virus-associated neurological disease: 3 with dementia, 2 with peripheral neuropathy, 1 with dementia and peripheral neuropathy, and 1 with T-10 paraplegia. Six of the patients showed improvement in their neurological dysfunction on being. Chemokine receptors pivotal for human immunodeficiency virus type 1 (HIV-1) infection in lymphocytes and macrophages (CCR3, CCR5, and CXCR4) are expressed on neural cells (microglia, astrocytes, and/or neurons). It is these cells which are damaged during progressive HIV-1 infection of the central nervous system. We theorize that viral coreceptors could effect neural cell damage during HIV-1. Human immunodeficiency virus-1 (HIV-1)/acquired immunodeficiency syndrome (AIDS) has been shown to be associated with a constellation of neuropsychiatric... DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals
Cognitive impairment is a frequent manifestation of advanced human immunodeficiency virus (HIV) infection. The response to antiretroviral medication is often partial and poorly sustained. Recent studies suggest that free radical production within the CNS and neuronal apoptosis may play important roles in the pathogenesis of HIV dementia. We conducted a randomized double-blind, placebo. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): This article reviews the changing epidemiology of HIV-associated dementia, current concepts of the different patterns of dementia under the influence of highly active antiretroviral therapy, and reviews therapeutic aspects. Journal of NeuroVirology (2003) 9, 205-221
Human immunodeficiency virus (HIV)-associated dementia is a neurodegenerative syndrome characterized by cognitive decline, personality change, and motor deficits. HIV-associated encephalitis (HAE), the neuropathology responsible for HIV-associated dementia involves the formation of multinucleated giant cells or syncytia Human immunodeficiency virus-associated dementia: an evolving disease JC McArthur, N Haughey, S Gartner, K Conant, C Pardo, A Nath, Journal of neurovirology 9 (2), 205-221 , 200 Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Neurology. 1998; 50(3): 645-51. 199 Janssen RS: Epidemiology of human immunodeficiency virus infection and the neurologic complications of the infection. Semin Neurol. 1992, 12 (1): 10-17. CAS PubMed Google Scholar 8. McArthur JC, Sacktor N, Selnes O: Human immunodeficiency virus-associated dementia. Semin Neurol. 1999, 19 (2): 129-150
The acquired immunodeficiency syndrome dementia as the presenting or sole manifestation of human in-numodeficiency virus infection. Safai, B, Brunetti, A, Perno, CF, Scmidt, PJ, Larson, SM, Myers, CE, Broder, S. Response of human-immunodeficiency-virus-associated neurological disease to 3′-azido-3′-deoxythymidine Dementia is chronic, global, usually irreversible deterioration of cognition. HIV-associated dementia (AIDS dementia complex) may occur in the late stages of HIV infection. Unlike almost all other forms of dementia, it tends to occur in younger people. Dementia should not be confused with delirium, although cognition is disordered in both Human Immunodeficiency Virus‐Associated Dementia: Clinical Aspects, Biology, and Treatment AIDS, Vol. 21, No. 14 New Insights into the Neuroimmunity of SIV Infection by Magnetic Resonance Spectroscop Introduction. Various degrees of synaptic pruning and neuronal apoptosis are seen in human immunodeficiency virus type 1 (HIV-1)-positive subjects in the late stage of infection of their brain (Ellis et al., 2007).These abnormalities culminate in neurocognitive deficits termed HIV-associated neurocognitive disorders, and especially in their more severe form, or HIV-associated dementia (HAD)
McArthur, J. C. et al. Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann. Neurol. 42 , 689-698 (1997) Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain. Ann Neurol. 1997; 42 : 689-698 Crossre Change in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretrovairal therapy. Annals of Neurology, 63, 213-221.doi10.1002/ana.21225 Logi 16 Bhaskaran K, Mussini C, Antinori A, et al. Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy. Ann Neurol 2008;63(2):213-221. Crossref, Medline, Google Schola Human immunodeficiency virus associated intracranial aneurysms: report of three adult patients with an overview of the literature. G Modi 1, K Ranchod 1, A detailed blood workup excluded treatable causes of dementia. The only relevant finding was a positive HIV test and a CD4 count of 164 cells/ml. The patient was not receiving.
Human immunodeficiency virus (HIV) infection is known to cause brain injury and neurocognitive impairment, variously termed HIV associated dementia or AIDS dementia complex (ADC), and primarily affecting areas of mental processing, behaviour, and motor control. 1- 3 Although usually considered a late complication, for reasons that have remained unclear, it can present as the sole or primary. Human immunodeficiency virus (HIV)-associated cognitive impairment involves behavioral, motor, and neuropsychological deficits that may eventually progress to dementia. 1 Cognitive deficits are secondary to brain injury in response to proinflammatory cytokines, chemokines, and neurotoxic HIV viral proteins (eg, gp120). 2,3 Microscopic pathologies include inflammatory infiltrates, myelin pallor. Objective: HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is critical for diagnosing this condition. The objective of this study was to evaluate the sensitivity and specificity of a new screening test for HIV dementia, the International HIV Dementia Scale. human immunodeficiency virus-associated mild neurocognitive disorder , HIV-associated dementia, distal sensory polyneuropathy, CNS opportunistic infections, seizure, headache, and myopathy. [sup] As a result, further image studies (brain or spinal magnetic resonance imaging) and neuromuscular tests should be arranged early for. Bergonzini V , Calistri A , Salata C , Del Vecchio C , Sartori E , Parolin C , Palù G (2009) Nef and cell signaling transduction: A possible involvement in the pathogenesis of human immunodeficiency virus-associated dementia. J Neurovirol 15, 238-248. [163
Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis 2000;30:S5-14. 127. Brodt HR, Kamps BS, Gute P, Knupp B, Staszewski S, Helm EB. Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy Altered White Matter Integrity in Human Immunodeficiency Virus-Associated Neurocognitive Disorder: A Tract-Based Spatial Statistics Study Se Won Oh, MD, 1 Na-Young Shin, MD, 2 Jun Yong Choi, MD, PhD, 3 Seung-Koo Lee, MD, PhD, 4 and Mi Rim Bang, MS 2 1 Department of Radiology, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea.: 2 Department of Radiology, College of Medicine, The. Longitudinal evaluation of language impairment in youth with perinatally acquired human immunodeficiency virus (HIV) and youth with perinatal HIV exposure. Journal of the Pediatric Infectious Diseases Society, 5 (Suppl 1), S33 - S40. doi: 10.1093/jpids/piw04 Objective: Human immunodeficiency virus (HIV) infection has been known to damage the microstructural integrity of white matter (WM). However, only a few studies have assessed the brain regions in HIV-associated neurocognitive disorders (HAND) with diffusion tensor imaging (DTI) The most severe HAND diagnosis, human immunodeficiency virus-associated dementia, is rare, but milder forms of impairment are common, even among those receiving combination antiretroviral therapy who have minimal comorbidities 3 3. Heaton RK, Clifford DB, Franklin DR Jr, Woods SP, Ake C, Vaida F, et al. HIV-associated neurocognitive disorders.
Churchill MJ, Wesselingh SL, Cowley D, Pardo CA, McArthur JC, Brew BJ, Gorry PR. COVID-19 second-generation vaccine research. Support Burnet's second-generation COVID-19 vaccine research Human immunodeficiency virus type 1 (HIV-1) is present in the central nervous system (CNS) during all stages of HIV infection and accounts for the high prevalence of dementia during advanced AIDS (2, 3, 11).In addition, there is evidence that the CNS is a distinct compartment for viral replication (17, 19).Various antiretroviral regimens have been shown to lower the plasma HIV-1 RNA load to.
(2005). Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: Results from an urban observational cohort. Journal of Neurovirology: Vol. 11, No. 3, pp. 265-273 Neurologic manifestations are frequent in human immunodeficiency virus type 1 (HIV-1) infection. In the era before combined antiretroviral therapy (ART) or in settings where antiretroviral drugs are not available, neurologic disease constituted the initial presentation in 10% of patients, and neurologic complications developed in 30% to 50% during the course of the disease. 1, 2 Autopsies have. Apolipoprotein-E genotype and human immunodeficiency virus-associated neurocognitive disorder: the modulating effects of older age and disease severity Stella E Panos,1,2 Charles H Hinkin,1,2 Elyse J Singer,3 April D Thames,1,2 Sapna M Patel,1,2, Janet S Sinsheimer,4 AC Del Re,5 Benjamin B Gelman,6 Susan Morgello,7 David J Moore,8 Andrew J Levine31Department of Psychiatry and Biobehavioral. Changing patterns of human immunodeficiency virus-associated neuropathology . Abstract. This paper describes the evolution of the pathogenic concepts associated with the infection by the human immunodeficiency virus (HIV), with emphasis to the pathology of the nervous system. (HIV-dementia). In addition, although antiretroviral therapy.
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Many patients infected with human immunodeficiency virus-1 (HIV-1) develop a syndrome of neurologic deterioration known as HIV-associated dementia (HAD). Neurons are not productively infected by HIV-1; thus, the mechanism of HIV-induced neuronal injury remains incompletely understood R. equi infection is increasing in prominence in immunocompromised humans, particularly those infected with human immunodeficiency virus (9, 12, 27). Immunodeficiency Syndrome Dementia. Human immunodeficiency virus infection and acquired immunodeficiency syndrome dementia com. Longitudinal Stud HIV-1-associated dementia remains a common subacute to chronic central nervous system degeneration in adult and pediatric HIV-1 infected populations. A number of viral and host factors have been implicated including the HIV-1 120 kDa envelope glycoprotein (gp120). In human post-mortem studies using confocal scanning laser microscopy for microtubule-associated protein 2 and synaptophysin. Tanzania, like other sub-Saharan African countries, has been severely affected by the human immunodeficiency virus 1 (HIV-1) epidemic. About 12% of the population of Dar es Salaam, the capital city, have been reported to be infected by the virus.1 Infection with HIV-1 frequently affects the brain as well as the lymphoreticular system; HIV-1 has been isolated from the cerebrospinal fluid of. The incidence of non-Hodgkin lymphoma (NHL) is increased more than 100-fold in individuals infected with the human immunodeficiency virus (HIV). 1 NHL in the HIV-infected population is characterized by a high incidence rate of high grade histology and extranodal involvement, 2 conferring a particularly poor prognosis. Involvement of the central nervous system (CNS) also frequently occurs in. Abstract. BACKGROUND Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are defined according to their diagnostic degrees as follows: asymptomatic neurocognitive impairment, mild neurocognitive disorder, and HIV-associated dementia